When Immune Tolerance Fails: From Mechanisms to Clinical Phenotypes
Günnur Deniz
Immune tolerance preserves the balance between an effective immune response and the protection of healthy tissues. Its failure can lead to autoreactive responses and a wide range of autoimmune and immune-mediated diseases. Despite their diverse clinical presentations, these disorders often share common features, including impaired regulatory mechanisms, altered immune checkpoints, (...)
Maternal Gut Dysbiosis Exacerbates Offspring Susceptibility to Collagen-Induced Arthritis in Mice
Fatmanur Dündar
The critical role of the gut microbiota in organismal homeostasis and immune system development is increasingly being understood through numerous studies.
and others
Association of CTLA-4 Gene Polymorphisms and Serum Soluble CTLA-4 Levels with Psoriasis Vulgaris
Nanees H. Kamel
Psoriasis is a long-term, immunologically driven inflammatory cutaneous disorder characterized by recurrent flare-ups, scaling, and erythema. The estimated worldwide prevalence of psoriasis is around 3%–4%, with psoriasis vulgaris (Pv) representing the most common clinical subtype. According to (...)
and others
August 2026
VOLUME 14
| ISSUE 2
ISSN 1301-109X | e-ISSN 2147-8325
Association Between Vitamin D Status, Regulatory T Cells, and Disease Severity in Pediatric Systemic Lupus Erythematosus
Wisnu Barlianto
Contrary to its name, vitamin D is not a vitamin, but a steroid hormone. Vitamins act as antioxidants or cofactors in enzymatic reactions and are primarily obtained through the diet. In contrast, vitamin D is produced by activating (...)
and others
Immune-Biochemical Stratification Identifies the Pure Primary Biliary Cholangitis Phenotype in AMA-Positive Individuals
Emrah Salman
and Sibel Gökay
Primary biliary cholangitis (PBC) is a chronic immune-mediated cholestatic liver disease marked by progressive destruction of small intrahepatic bile ducts, potentially leading to fibrosis and cirrhosis if left (...)
Immune Dysregulation: Mechanisms of Tolerance Failure, Clinical Spectrum, and Emerging Therapeutic Strategies
Maryam Aladodo
Immunology occupies a unique position among the biomedical sciences: it is simultaneously the study of protection and the study of destruction. The very mechanisms that defend the host against an almost infinite variety of microbial threats -pathogen recognition, lymphocyte activation, antibody production, inflammatory cascades- can, under circumstances that are still incompletely understood, turn against the self (...)
and others
Anti-ADAMTSL5 and Anti-K17 Autoantibodies in Psoriasis: Diagnostic Performance and Associations with Systemic Inflammation
Dina A. M. Al-Faidhi
and Rojan G.M. Al-Allaff
Psoriasis is a chronic immune-mediated inflammatory skin disease that can be challenging to distinguish from clinically similar dermatoses. Early-stage psoriasis may be confused with atopic dermatitis, nummular eczema, and pityriasis rosea. This diagnostic uncertainty can lead to a delay in diagnosis, which is important because timely treatment may help reduce the risk of systemic comorbidities, including psoriatic arthritis and metabolic (...)
MOST ACCESSED ARTICLES
Overview of Autoimmunity: Classification, Disease Mechanisms, and Etiology
Shanti Narayanappa Koppala
and Vaishnavi Guruprasad
December 31, 2023
Eosinophylic Esophagitis and Medical Nutrition Treatment
Menşure Nur Çelik
and Efsun Karabudak
April 30, 2020
Gene Regulation of MHC Class-I and MHC Class-II
Şule Karataş
and Fatma Savran Oğuz
December 31, 2020
Evaluation of T Lymphocyte Subgroups in Patients with Chronic Lymphocytic Leukemia
Metin Yusuf Gelmez
and others
April 30, 2020
RECENT ISSUES
View Index