ISSN 1301-109X | e-ISSN 2147-8325
Northwestern Medical Journal
Evaluation of Immunoglobulins, CD4/CD8 T Lymphocyte Ratio and Interleukin-6 in COVID-19 Patients [Turk J Immunol]
Turk J Immunol. 2020; 8(3): 129-134 | DOI: 10.25002/tji.2020.1347

Evaluation of Immunoglobulins, CD4/CD8 T Lymphocyte Ratio and Interleukin-6 in COVID-19 Patients

Marwan Mahmood Saleh1, Abduladheem Turki Jalil2, Rafid A. Abdulkereem3, Ahmed Aduljabbar Suleiman4
1College of Applied Sciences, University of Anbar, Anbar, Iraq
2Yanka Kupala State University of Grodno Faculty of Biology and Ecology
3Institute of Genetic Engineering and Biotechnology for Post Graduate Studies- University of Baghdad, Baghdad, Iraq
4College of Science-Biotechnology Department, University of Anbar, Anbar, Iraq

Introduction: The outbreak of novel coronavirus COVID-19 infections that started in China late 2019 has spread
rapidly and cases have been recorded worldwide. So, in this study, we sought clarification of the clinical characteristics
and importance of changing the lymphocyte group, antibodies, CD markers, and interleukin-6 in the serum of
COVID-19 patients, which may help to clarify the pathogen and develop new biomarkers.
Material and Methods: Venous blood samples had been accumulated from patients before taking any medications.
Sera had been separated and saved at (-20°C) until analysis. Serum anti-SARS-CoV-2 immunoglobulins (IgG, IgA,
and IgM) were determined in plasma samples using enzyme-linked immunosorbent assays (ELISA) and Serum IL-6
was assessed.
Results: Median IgM (p=0.001), IgG (p<0.0001), and IgA (p<0.001), were decreased in patients comparing with
control the control group. There is a significant decrease in CD3+ and CD4+ cells compared to healthy individuals in
patients infected with COVID-19 (p<0.0001). CD19+ cell count decreased in COVID-19 patients compared to that
of the control group (p<0.0001). After calculating CD4+/CD8+ cell ratio decreased in COVID-19 patients (p<0.0001).
However, CD56+ cells were found to be increased (p<0.0001).
Conclusions: IgM, IgG, IgA levels and CD19+, CD4+ cells, CD4+/CD8+ cell ratio were found to be decreased whereas
CD8+, CD3+, CD4+ cells were detected to be increased in COVID-19 patients compared to those of healthy controls.

Keywords: IL-6, COVID-19, IgG, IgA, IgM, CD markers

COVID-19 Hastalarında İmmünoglobülinler, CD4+/CD8+ T Lenfosit Oranları ve Interlökin-6 Düzeyinin Değerlendirilmesi

Marwan Mahmood Saleh1, Abduladheem Turki Jalil2, Rafid A. Abdulkereem3, Ahmed Aduljabbar Suleiman4
1
2
3
4

Giriş: Çin’de 2019 yılı sonlarına doğru başlayan Yeni Koronavirüs Hastalığı (COVID-19) hızla tüm dünyaya yayıldı.
Bu çalışmada, COVID-19 olan hastaların serumlarındaki interlökin-6 (IL-6) düzeyleri, değişen lenfosit alt-grupları ve
antikorlar araştırılarak bu patojenin daha net anlaşılması ve yeni biyobelirteçlerin geliştirilşmesi amaçlandı.
Gereç ve Yöntemler: Hastalardan herhangi bir ilaç kullanmadan önce venöz kan örnekleri toplandı. Bu kanlardan
serumlar elde edildi ve bu serumların irdelenmesine kadar (-20°C’de) saklandı. Serumdaki SARS-Cov-2’ye karşı
gelişmiş immünoglobulinler (IgG, IgA ve IgM) ve IL-6 düzeyi ELISA testi ile ölçüldü.
Bulgular: Kontrol grubu ile karşılaştırıldığında, COVID-19 hastalarında IgM (p=0.001), IgG (p<0.0001) ve IgA
(p<0.001) seviyeleri anlamlı derecede azaldı. Benzer şekilde CD3+ ve CD4+ T hücreleri kontrollere göre anlamlı dercede
düşük saptandı (p<0.0001). CD19+ B hücreleri ve CD4+/CD8+ hücre oaranları kontrol grubuna göre daha düşük
(p<0.0001), buna karşılık CD56+ hücrelerde artış saptandı.
Sonuçlar: COVID-19 hastalarında IgM, IgG ve IgA düzeyleri ile CD19+ ve CD4+/CD8+ hücrelerin oranı sağlıklı
kontrollere göre daha düşük, CD8+, CD3+, CD4+ ve IL-6 düzeyleri daha yüksek olarak saptanmıştır.

Anahtar Kelimeler: IL-6, COVID-19, IgG, IgA, IgM, CD belirteçleri

Marwan Mahmood Saleh, Abduladheem Turki Jalil, Rafid A. Abdulkereem, Ahmed Aduljabbar Suleiman. Evaluation of Immunoglobulins, CD4/CD8 T Lymphocyte Ratio and Interleukin-6 in COVID-19 Patients. Turk J Immunol. 2020; 8(3): 129-134

Corresponding Author: Marwan Mahmood Saleh
Manuscript Language: English
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